For many people facing chronic infections such as Lyme disease, Epstein–Barr virus (EBV), herpes simplex viruses (HSV-1 and HSV-2), or cytomegalovirus (CMV), the journey can be long, complex, and deeply frustrating.
Even after months—or years—of antibiotics, antivirals, herbal therapies, or IV treatments, symptoms can persist or return. Fatigue, pain, neurological symptoms, and immune dysregulation often linger, leaving patients searching for something more targeted and lasting.
In recent years, both patients and clinicians have begun exploring innovative therapies that move beyond conventional antimicrobial approaches. One of the most promising among these is Supportive Oligonucleotide Therapy (SOT), also known as QRE-strain therapy or antisense oligonucleotide therapy.
What Is Supportive Oligonucleotide Therapy (SOT)?
At its core, SOT is a gene-silencing therapy. It works by creating a short synthetic strand of genetic material—called an oligonucleotide—that binds to a precise sequence in the pathogen’s DNA or RNA.
When it binds, it blocks the pathogen’s ability to produce a protein essential for survival or replication. In simple terms, it’s like removing a key page from the pathogen’s instruction manual. Without that information, the microbe can no longer reproduce efficiently, and its population gradually declines.
This approach builds upon decades of research in antisense and RNA-based medicine. In fact, the first FDA-approved antisense drug, fomivirsen (Vitravene), was licensed in 1998 for treating cytomegalovirus (CMV) retinitis. Since then, gene-silencing strategies have been applied in conditions such as spinal muscular atrophy, high cholesterol, and cancer.
Now, similar principles are being adapted to address chronic bacterial and viral infections—including Lyme disease and co-infections like Bartonella and Babesia, as well as chronic viral conditions like EBV and HSV.
How SOT Works
The process of SOT treatment involves several carefully designed steps:
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Blood Draw & Testing
A blood sample is taken and analyzed using molecular techniques (like PCR) to identify which pathogens are active in your body. -
Custom Design
A specialized lab designs a patient-specific oligonucleotide that targets the exact gene sequence of your pathogen. Newer technologies, such as QRE-strain engineering (Quasispecies Resistant Engineered strain), account for variations between strains, improving precision and efficacy. -
Infusion
Once the custom therapy is prepared, it’s administered as a single intravenous (IV) infusion in the clinic. -
Ongoing Action
Unlike antibiotics or antivirals that are metabolized quickly, SOT molecules remain active for months—often up to six months—continuously working “day and night” to suppress pathogen replication.
Clinical Research and Results
Early studies and clinical observations are encouraging. In pilot trials, SOT has shown measurable reductions in pathogen DNA, including Borrelia burgdorferi (the bacterium that causes Lyme disease) and Epstein–Barr virus.
According to reports from RGCC laboratories, which specialize in genetic-based therapies:
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95% of Lyme disease and tick-borne illness patients show a positive clinical response.
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91% of patients with chronic viral infections such as EBV experience improvement.
These results suggest that SOT may help patients whose infections have proven resistant to traditional therapies. Still, it’s important to recognize that SOT for Lyme and viral infections is considered an emerging, experimental therapy, and larger clinical trials are needed to confirm its long-term efficacy.
Why Patients Are Drawn to SOT
SOT offers several unique advantages that set it apart from conventional treatment approaches:
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Precision Targeting: It silences a specific gene within the pathogen, leaving beneficial microbes untouched.
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Long-Lasting Effect: A single infusion remains active for months, reducing the need for daily medications.
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Immune-Independent Action: Because it acts directly at the genetic level, SOT doesn’t rely on immune strength—ideal for patients with immune dysfunction.
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Integration-Friendly: It can be combined with IV nutrient therapy, detoxification, and other integrative approaches to support overall healing.
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Minimal Side Effects: Most patients tolerate SOT well, experiencing far fewer side effects than with repeated antibiotic or antiviral courses.
What to Expect at Jyzen
When receiving SOT therapy at Jyzen, patients can expect a smooth and supportive process:
The Steps:
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Payment for therapy vial
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Blood draw and pathogen testing
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~6-week period while your custom oligonucleotide is created
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IV infusion administered in the clinic (sessions last about 1–2 hours)
Preparation Tips:
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Complete any required lab work before your appointment.
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Stay hydrated the day before and day of your infusion.
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Eat a light, healthy meal a couple of hours prior.
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Avoid alcohol, caffeine, and strenuous exercise for 24 hours before.
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Plan for rest following your treatment—no major activities that day.
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Wear comfortable clothing and bring something relaxing (a book, music, etc.).
The Future of RNA-Based Medicine
The field of RNA and gene-silencing therapies is expanding rapidly, transforming medicine as we know it. From cancer to metabolic disorders and chronic infections, these therapies are redefining how we target disease at its most fundamental level—the genetic code.
Supportive Oligonucleotide Therapy may still be emerging, but its scientific foundation is solid, and its results are inspiring hope for many who have felt stuck in their healing journey.
At Jyzen, we’re proud to offer this advanced therapy in the Bay Area, combining cutting-edge science with an integrative, compassionate approach to whole-person healing.
Ready to Learn More?
If you’ve struggled with chronic infections and haven’t found the answers you’re looking for, SOT may be the breakthrough your body has been waiting for.
Contact Jyzen to schedule an appointment with Dr. Maria Marian and discover whether Supportive Oligonucleotide Therapy is right for you.